This study aimed to determine the relationship between the quality of life and social alienation of drug addicts. It also aimed at Identify indicators for social workers roles with addicts for helping them to improve their quality of life as well to reduce their sense of social alienation. A purpose sample of (92) was selected. The study found that there is a statistically significant inverse relationship at the level of significance (0.01) between the quality of life and social alienation of drug addicts, the level of quality of life dimensions for drug addicts is low, and the level of the dimensions of social alienation for drug addicts is medium.