The study aimed to determine the level of job stress among social workers and its relation to the quality of work life. In light of this, the job stress scale and the quality of work life scale were applied to the study sample 180 social workers working in special intellectual education schools in Cairo Governorate. The results of the study indicate that the level of job stress of social workers in special intellectual education schools is high with the arithmetic mean of 4.35. As for the quality of work life of the social workers (sample study), it is low; the arithmetic mean is equal to (1.59). This means, whenever the job stress in a sample of study from social workers increases, the quality of work life decreases. Conversely, whenever the job stress decreases, their quality of work life increases. These results were consistent with research hypotheses. The study found out that, quality of work life has a role in reducing the phenomenon of job stress among social workers in special intellectual education schools. This study is one of the rare studies, which link the variable dimensions of the quality of work life and job stress to social workers.