Background and study aim: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder ‎with 10%-15% prevalence. Altered intestinal microflora is common in ‎IBS so the current study aims to figure out the effect of fecal microbiota ‎transplant (FMT) on patients suffering from IBS‎‎‎‎‎.‎
Patients and Methods: The study included 30 patients attended internal medicine clinic of the ‎Suez Canal University Hospital, Ismailia, Egypt. All were inquired ‎about IBS symptoms using Rome III criteria, patients classified into ‎three groups: group A: healthy donors, group B: patients who received ‎Mebeverine and Simethicone and group C: patients who managed by ‎FMT. Patients were asked to register their symptoms using the IBS-‎severity scoring system (IBS- SSS) after 2 weeks and one month. The ‎stool for FMT of the donors was prepared and introduced to patients ‎via retention enema‎.‎
Results: Significant improvement of quality of life (QoL) in group B was 47.74 ± ‎‎40.43% after 2 weeks and 26.14 ± 50.28% after one month. In group ‎C, the improvement was 82.57 ± 20.94% after 2 weeks that became ‎79.57 ± 21.49% after one month. The pain score before treatment was ‎‎70 in group B and 75 in group C then after 2 weeks pain score was  35 ‎in group B and 20 in group C and after one month pain score was 70 in ‎group B and 20 in group C. Patients in both groups B and C have ‎constipation that improved markedly in group C more than group B‎.
Conclusion: FMT is a good method of treatment of IBS patients ‎‎‎‎‎‎‎‎‎.