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245475

Assessment of Serum Vitamin D and Total Calcium Levels in COVID-‎‎19 Infected Patients and Their Relation to Disease Severity

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Infectious diseases

Abstract

Background and study aim: COVID-19 is a  highly contagious viral infection that was initially discovered in late 2019 in ‎China. Vitamin D was proposed as a COVID-19 severity indicator by many authors. However, the ‎role of hypocalcemia has not yet been well established. So we evaluated serum levels of vitamin D ‎and total calcium in adult patients infected with COVID-19 and correlated vitamin D and calcium ‎levels with the severity and prognosis of the COVID-19 infection‎‎‎.‎
Patients and Methods: ‎‎‎ Our study evaluated 98 patients (50 females, 48 males) who were diagnosed with positive SARS-‎CoV-2 polymerase chain reaction.  The patients were categorized into severe and non-severe ‎COVID-19 based on the Egyptian protocol for the management of COVID-19 patients. Serum ‎vitamin D and calcium levels were estimated in all patients‎‎.‎
Results: In severe COVID-19 individuals, serum vitamin D levels were significantly lower (P = 0.04). ‎However, there was no statistically significant change in serum calcium levels between severe and ‎non-severe COVID-19 patients (P = 0.7) despite the high prevalence of hypocalcemia in our ‎cohort (88%, 86/98). There was no statistically significant difference in the blood levels of both ‎vitamin D and calcium between the improved group of patients and the death group (P = 0.5, 0.1 ‎respectively)‎‎‎‎‎‎.
Conclusion: Vitamin D deficiency is a risk factor for disease progression and severity in COVID-19 patients. ‎Hypocalcemia is not linked to COVID-19 severity despite its high prevalence in these patients. ‎However, to back up these findings, more research with bigger sample size is required‎ ‎‎‎‎‎‎‎‎.

DOI

10.21608/aeji.2022.132786.1215

Keywords

calcium, COVID-19, Vitamin D

Authors

First Name

Mona

Last Name

Abdelrahman

MiddleName

M

Affiliation

Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Sohag ‎University,Sohag, Egypt.

Email

monamohamed@med.sohag.edu.eg

City

-

Orcid

0000-0002-8784-848X.

First Name

Shimaa

Last Name

Hemdan

MiddleName

B

Affiliation

Medical Biochemistry Department, Faculty of Medicine, Sohag University, Sohag, Eygpt

Email

shimaabadwy@med.sohag.edu.eg

City

-

Orcid

-

First Name

Ashraf

Last Name

Alkabeer

MiddleName

M

Affiliation

Internal Medicine Department, Faculty of Medicine, Al-Azhar University, Assuit, Eygpt.

Email

ashrafkabeer5@gmail.com

City

-

Orcid

-

First Name

Mustafa

Last Name

Haridy

MiddleName

A

Affiliation

Department of Hepatology, Gastroenterology and Infectious Diseases, Faculty of Medicine, Al-Azhar University, Assuit, Eygpt.

Email

mustafa_haridy@azhar.edu.eg

City

-

Orcid

-

First Name

Mohammed

Last Name

Mahmoud

MiddleName

A

Affiliation

Anesthesia and Surgical ICU Department, Faculty of Medicine, Sohag University, Sohag, Eygpt.

Email

mahroos_mohammed@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Nour Eldin

MiddleName

N

Affiliation

Internal Medicine Department, Faculty of Medicine, Sohag University, Sohag, Eygpt.

Email

ahmednagah3000@yahoo.com

City

-

Orcid

-

First Name

Asmaa

Last Name

Khalaf

MiddleName

R

Affiliation

Chest Diseases and Tuberculosis Department, Faculty of Medicine, Sohag University, Sohag, Eygpt.

Email

dr.asmaa29680@yahoo.com

City

-

Orcid

-

First Name

Doaa

Last Name

Bardis

MiddleName

SM

Affiliation

Clinical and Chemical Pathology Department, Faculty of Medicine, Sohag University,Sohag, Egypt.

Email

doaa.sayed@med.sohag.edu.rg

City

-

Orcid

-

First Name

Amira

Last Name

Maher

MiddleName

-

Affiliation

Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Sohag ‎University,Sohag, Egypt.

Email

amiramaher@med.sohag.edu.eg

City

-

Orcid

-

Volume

12

Article Issue

3

Related Issue

36292

Issue Date

2022-09-01

Receive Date

2022-04-11

Publish Date

2022-09-01

Page Start

208

Page End

217

Print ISSN

2090-7613

Online ISSN

2090-7184

Article File

AEJI_Volume 12_Issue 3_Pages 208-217.pdf

PDF . 478.9kB

Link

https://aeji.journals.ekb.eg/article_245475.html

Detail API

https://aeji.journals.ekb.eg/service?article_code=245475

Order

3

Type

Original Article

Type Code

616

Publication Type

Journal

Publication Title

Afro-Egyptian Journal of Infectious and Endemic Diseases

Publication Link

https://aeji.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023