Neuromeningeal cryptococcosis (NC) ,  is a mycosis caused by an encapsulated yeast fungus, named Cryptococcus neoformans (CN) , primarily affecting immunocompromised patients, particularly those with human immunodeficiency virus (HIV), but may rarely affect immunocompetents. We report the observations of two immunocompetent adult patients with neuromeningeal cryptococcosis, they are fifty six years old and forty six years old, the disease started in both patients with symptoms of meningoencephalitis, the diagnosis was established by the presence of cryptococcus in the cerebrospinal fluid (CSF) and in the serum by the detection of the capsular polysaccharide antigen by latex agglutination. The search for the common etiologies causing the immunosuppressant has been negative. Amphotericin B treatment was started. The evolution was favorable in the first case and fatal in the second one causing his death with cerebral engagement. We conclude from these observations, that neuromeningeal cryptococcosis can occur in any patient immunocompetent.