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222818

The Clinical Utility of Serial Procalcitonin and Procalcitonin Clearance in Predicting the ‎Outcome of COVID-19 Egyptian Patients

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Infectious diseases

Abstract

Background and study aims: The 2019 coronavirus pandemic (COVID-19) poses a severe worldwide health danger. Delicate ‎diagnostics that accurately predict illness prognosis are required to guide appropriate action. The ‎purpose of this study was to explore if serial procalcitonin (PCT) measurement could predict ‎COVID-19 patient outcomes using PCT clearance (PCT-c) as a dynamic change ‎indicator‎.‎
Patients and Methods: ‎‎‎ ‎ Serial PCT and PCT-c values of 63 COVID-19 Egyptian patients were compared between ‎survivors and non-survivors throughout the first five days of their hospitalization‎ ‎.‎
Results: Serial PCT levels in non-survivors were greater (p <0.001) than in survivors and increased over ‎time. PCT-c levels were lower (p <0.01) and decreased throughout time. The initial PCT value ‎alone predicted in-hospital mortality with 87.3 % accuracy at a 0.80 ng/ml cut-off. Serial ‎measurement improved COVID-19 outcome prediction‎‎‎‎‎‎‎‎‎.
Conclusion: Serial PCT measurement is effective in predicting COVID-19 patient outcomes. PCT-c can also ‎be used to determine PCT progressive kinetics‎ ‎‎‎‎‎‎‎‎‎.

DOI

10.21608/aeji.2022.114885.1197

Keywords

clearance, COVID-19, mortality, Procalcitonin, Serial

Authors

First Name

Sara

Last Name

Taha

MiddleName

I

Affiliation

Department of Clinical Pathology/Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Email

dr_sara_ib@med.asu.edu.eg

City

Cairo

Orcid

0000-0001-8224-8701

First Name

Aalaa

Last Name

Shata

MiddleName

K.

Affiliation

Department of Pulmonary Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Email

aalaashata@yahoo.com

City

Cairo

Orcid

-

First Name

Shereen

Last Name

Baioumy

MiddleName

A.

Affiliation

Department of Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Email

drshereenatef@yahoo.com

City

Cairo

Orcid

0000-0002-2188-6790

First Name

Shaimaa

Last Name

Fouad

MiddleName

H.

Affiliation

Department of Internal Medicine / Allergy and Clinical Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Email

shaimaahani@med.asu.edu.eg

City

Cairo

Orcid

0000-0003-4052-9454

First Name

Aya

Last Name

Moussa

MiddleName

H.

Affiliation

Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Email

ayahisham@med.asu.edu.eg

City

Cairo

Orcid

0000-0003-4680-2204

First Name

Eman

Last Name

El-Sehsah

MiddleName

M.

Affiliation

Department of Medical Microbiology and Immunology, Mansoura Faculty of Medicine, Mansoura, Egypt.

Email

emanalsahsah@gmail.com

City

Cairo

Orcid

-

First Name

Dina

Last Name

Sallam

MiddleName

-

Affiliation

Department of Pediatrics / Pediatric Nephrology, Faculty of medicine, Ain Shams University, Cairo, Egypt.

Email

dinaebrahim2008@med.asu.edu.eg

City

Cairo

Orcid

-

First Name

Mariam

Last Name

Youssef

MiddleName

K.

Affiliation

Department of Clinical Pathology/ Hematology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Email

dr.mariam_karam@hotmail.com

City

Cairo

Orcid

0000-0003-2075-3889

Volume

12

Article Issue

2

Related Issue

34231

Issue Date

2022-06-01

Receive Date

2022-01-05

Publish Date

2022-06-01

Page Start

115

Page End

123

Print ISSN

2090-7613

Online ISSN

2090-7184

Article File

AEJI_Volume 12_Issue 2_Pages 115-123.pdf

PDF . 308.5kB

Link

https://aeji.journals.ekb.eg/article_222818.html

Detail API

https://aeji.journals.ekb.eg/service?article_code=222818

Order

3

Type

Original Article

Type Code

616

Publication Type

Journal

Publication Title

Afro-Egyptian Journal of Infectious and Endemic Diseases

Publication Link

https://aeji.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023