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207360

Pattern of Serum Vitamin D in Individuals with non-Alcoholic Fatty Liver and ‎its Relation to Metabolic Dysfunction

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Hepatology

Abstract

Background and study aim: Vitamin D has extensive anti-fibrotic, anti-inflammatory, and insulin-sensitizing ‎properties, in addition to involvement in immune-metabolic pathways within the ‎gut-adipose tissue-liver axis. This study aims to assess the association between ‎vitamin D deficiency, metabolic dysfunction and NAFLD which is still ‎controversial‎‎‎‎‎‎.
Patients and Methods: Cross sectional study that included 170 subjects; 85 cases with fatty liver and 85 ‎healthy controls.  After measurement of BMI, both studied groups were subjected ‎to the following laboratory investigations: vitamin D, liver enzymes, random ‎blood glucose, HbA1C, cholesterol, TG, LDL, HDL and uric acid‎.‎
Results: Vitamin D deficiency was associated with many metabolic dysfunction ‎parameters. Regarding NAFLD: in univariate analysis, vitamin D deficiency, male ‎sex, overweight and obesity, hypercholesterolemia, hyper-glycaemia, and elevated ‎liver enzymes were the risk factors. Meanwhile multivariate analysis showed that ‎the risk factors included male sex, overweight and obesity. Sensitivity and ‎specificity of vit D deficiency, at a cutoff value of ≤18.5 mg/mL, were 68.24% ‎and 52.92%, respectively. Sensitivity and specificity of hypertriglyceridemia, with ‎a cutoff value of >113 mg/dL, were 77.65% and 48.24%, respectively.  At cutoff ‎value of >5.2%, sensitivity and specificity of HBA1C were 69.41% and 56.47%, ‎respectively‎‎.
Conclusion: Vitamin D deficiency is associated with high prevalence of metabolic changes. ‎Thus, early detection and treatment of such deficiency can improve fatty liver ‎disease and its associated metabolic changes, hence, preventing progression into ‎liver cirrhosis‎‎‎‎‎‎‎‎‎.

DOI

10.21608/aeji.2021.100732.1188

Keywords

Fatty Liver, Vitamin D Status, dyslipidemia, Obesity, Metabolic Dysfunction

Authors

First Name

Fatma

Last Name

Moussa Mohamed

MiddleName

R

Affiliation

Department of Infectious Diseases, Gastroenterology and Hepatology, Faculty of Medicine, Suez ‎University, Suez, Egypt‎.‎

Email

frageh2002@hotmail.com

City

Suez

Orcid

-

First Name

Samar

Last Name

Ahmed

MiddleName

S

Affiliation

Department of Public Health and Community Medicine, Faculty of Medicine, Suez University, ‎Suez, Egypt‎.‎

Email

samarsayedahmed01@gmail.com

City

Suez

Orcid

-

First Name

Shaymaa Abdelraheem

Last Name

Abdelhady

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt‎.‎

Email

shaymaa-abdelraheem@med.suez.edu.eg

City

ismaillia

Orcid

-

First Name

Mohamed

Last Name

Aboelmagd

MiddleName

-

Affiliation

Department of Endemic and Infectious Diseases, Faculty of Medicine, Suez Canal University, ‎Ismailia, Egypt‎ ‎.‎

Email

aboelmagd-tm@yahoo.com

City

ismalia

Orcid

-

First Name

Mohamed

Last Name

Farrag

MiddleName

-

Affiliation

Department of Critical Care Medicine, Faculty of Medicine, Misr University for Science and ‎Technology, Cairo, Egypt ‎.‎

Email

mohammedewais@gmail.com

City

cairo

Orcid

-

First Name

Mariam

Last Name

Hassan

MiddleName

-

Affiliation

Department of Internal Medicine, Ahmed Maher Teaching Hospital, Cairo, Egypt‎‎.‎

Email

mariamdarweesh11@gmail.com

City

-

Orcid

-

First Name

Naglaa

Last Name

Abd ‎Al Monem

MiddleName

-

Affiliation

Department of Tropical Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt‎.‎

Email

drnaglahyh@yahoo.com

City

Zagazig

Orcid

-

First Name

Ahmed Abd Elrazik

Last Name

Mohamed

MiddleName

-

Affiliation

Department of Radiodiagnosis, Alazhar University, Assiut, Egypt‎.‎

Email

ahmedmekily2@gmail.com

City

-

Orcid

-

First Name

Dalia

Last Name

Ghareeb

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez University, Suez, Egypt‎.‎

Email

daliaghareeb13@yahoo.com

City

-

Orcid

-

Volume

11

Article Issue

4

Related Issue

28882

Issue Date

2021-12-01

Receive Date

2021-10-19

Publish Date

2021-12-01

Page Start

412

Page End

422

Print ISSN

2090-7613

Online ISSN

2090-7184

Article File

AEJI_Volume 11_Issue 4_Pages 412-422.pdf

PDF . 334.0kB

Link

https://aeji.journals.ekb.eg/article_207360.html

Detail API

https://aeji.journals.ekb.eg/service?article_code=207360

Order

11

Type

Original Article

Type Code

616

Publication Type

Journal

Publication Title

Afro-Egyptian Journal of Infectious and Endemic Diseases

Publication Link

https://aeji.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023