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197111

Role of Eosinophilic Inflammation in Disease Severity among Egyptian COVID-19 Patients‎ ‎

Article

Last updated: 22 Jan 2023

Subjects

-

Tags

Infectious diseases

Abstract

Background and study aim: The coronavirus disease pandemic of 2019 (COVID-19) has created global health and economic ‎implications. All potential biomarkers, risk factors, therapy and preventative measures of the ‎disease has been thoroughly investigated. This study examined the relationship between ‎eosinophils and COVID-19 severity, as well as other clinical and laboratory markers of the disease‎‎‎‎.
Patients and Methods: ‎‎‎ In this retrospective study, we collected data from 162 patients' medical records including baseline ‎complete blood counts with differential total leucocytic counts (TLC). Descriptive and comparative ‎statistics were performed‎‎.‎
Results: Regarding disease severity, TLC significantly increased (p=0.019) and lymphocyte count ‎significantly decreased (p=0.003) with more severe disease but eosinophil count showed no ‎significant differences (p= 0.864). Patients admitted to the ICU showed no significant difference in ‎eosinophil count (p=0.551), they had significantly higher TLC (p≤0.001) and significantly lower ‎lymphocyte count (p≤0.001). No significant correlations (p > 0.05) were found between eosinophil ‎count and any of the laboratory markers of the disease, age of patients, or length of hospital stay‎‎‎.
Conclusion: Eosinophil count had no correlation with COVD-19 severity, while lymphopenia was a poor ‎prognostic marker‎‎‎‎‎‎‎.

DOI

10.21608/aeji.2021.91303.1168

Keywords

COVID-19, Eosinophils, lymphopenia, severity, total leucocytic count

Authors

First Name

Mariam

Last Name

Abdelmaksoud

MiddleName

F

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, ‎Egypt‎.‎

Email

dr_mariam_fathy@med.asu.edu.eg

City

Cairo

Orcid

-

First Name

Shaimaa

Last Name

Fouad

MiddleName

H

Affiliation

Department of Internal Medicine/Allergy and Clinical Immunology, Faculty of Medicine, Ain Shams University, Cairo, ‎Egypt‎.‎

Email

shaimaahani@med.asu.edu.eg

City

Cairo

Orcid

0000-0003-4052-9454

First Name

Hieba

Last Name

Ezzelregal

MiddleName

G

Affiliation

Department of Pulmonary Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt‎‎.‎

Email

hiebagamal24@med.asu.edu.eg

City

Cairo

Orcid

0000-0002-0872-7103

First Name

Shereen

Last Name

Baioumy

MiddleName

A

Affiliation

Department of Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, ‎Egypt‎‎.‎

Email

drshereenatef@yahoo.com

City

Cairo

Orcid

0000-0002-2188-6790

First Name

Sara

Last Name

Taha

MiddleName

I

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, ‎Egypt‎.‎

Email

dr_sara_ib@med.asu.edu.eg

City

Cairo

Orcid

0000-0001-8224-8701

Volume

11

Article Issue

4

Related Issue

28882

Issue Date

2021-12-01

Receive Date

2021-08-18

Publish Date

2021-12-01

Page Start

331

Page End

342

Print ISSN

2090-7613

Online ISSN

2090-7184

Link

https://aeji.journals.ekb.eg/article_197111.html

Detail API

https://aeji.journals.ekb.eg/service?article_code=197111

Order

3

Type

Original Article

Type Code

616

Publication Type

Journal

Publication Title

Afro-Egyptian Journal of Infectious and Endemic Diseases

Publication Link

https://aeji.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023