A new study in this issue of the Afro-Egyptian journal of infectious and endemic diseases ‎investigated the use of the PAPAS score (Platelet/Age/ Phosphatase/AFP/AST) for predicting EVs ‎in HCV-related cirrhotic patients. This study included patients at different stages of cirrhosis ‎‎(compensated and decompensated) who underwent screening EGD to detect the presence of EVs. ‎The PAPAS score and other non-invasive scores (APRI, FIB4, Lok Scor) were calculated and ‎compared their accuracy in predicting the development of EVs. The results of this study showed ‎that patients with EVs have a significantly higher PAPAS score than those without EVs. The ‎PAPAS index showed higher diagnostic accuracy than the other tests (APRI, FIB-4, and Lok ‎Score). PAPAS index AUCs were 0.939 for diagnosis of EVs with 86% sensitivity, 93.33% ‎specificity, 95.2% PPV, 73.7% NPV, and AUC 0.746 for detecting Large EVs with 94.87% ‎sensitivity, 86.43% specificity, 71.2% PPV, 86.7% NPV, indicating its usefulness in identifying ‎patients with large varices who require endoscopy. ‎