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191420

Measles IgG Antibodies: Is There a Protective Role in COVID 19 Pandemic?‎ ‎

Article

Last updated: 22 Jan 2023

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Subjects

-

Tags

Infectious diseases

Abstract

Background and study aim: Epidemiological   data reported lower death rates of COVID-19 cases   in countries with   higher & ‎recent coverage by measles containing vaccines. In this study we aim to identify measles IgG titer ‎in COVID-19 patients & correlate it with disease severity‎‎‎‎.
Patients and Method: ‎This is a Cross-sectional study where 78 patients admitted to Ain Shams University Quarantine ‎hospitals with positive PCR for SARS-CoV-2 were enrolled.  All patients underwent ‎quantification of serum measles IgG titer. Then classified according to the COVID-19 severity ‎into mild, moderate and severe‎‎.‎
Results: Measles IgG was positive in 53 patients (68%) with median of 1600 (IQR 1000-or3100), borderline ‎in 18 patients (23%) with median 250 (IQR 200-250) and negative in seven patients (9%) with ‎median 100 (IQR 80-120). Patients with positive measles IgG were   significantly older (56±16 ‎years)   than those with negative measles IgG ( 48±15 years) (P=0.03).No significant difference ‎was found in measles IgG titer between mild   , moderate and severe COVID19 cases. Intensity of ‎pulmonary involvement by CT chest   was not correlated with measles IgG titer. The median of ‎measles IgG titer of the ICU admitted patients and those who were not, was 1150 (IQR=600-3500) ‎and 1050 (IQR=200-1800) respectively (p=0.46).  No difference in measles IgG titer between ‎patients who recovered or died‎‎‎.
Conclusion: Severity of COVID-19 disease and its outcome seem to be  unaffected by measles IgG titer‎‎‎‎‎.

DOI

10.21608/aeji.2021.72615.1144

Keywords

SARS-COV2, COVID-19 pandemic, Measles IgG

Authors

First Name

Amira

Last Name

Al Balakosy

MiddleName

-

Affiliation

Department of Tropical Medicine, Faculty of Medicine, Ain Shams University ‎Abbasia square, Cairo, Egypt.‎

Email

drbalakosy@gmail.com

City

Cairo

Orcid

0000-0002-9229-6237

First Name

Mostafa

Last Name

Alfishawy

MiddleName

-

Affiliation

Infectious Diseases Consultants and Academic Researchers of Egypt committee, Cairo, Egypt.

Email

malfishaway@kasralainy.edu.eg

City

cairo

Orcid

-

First Name

Omnia

Last Name

Elnabawy

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Ain Shams ‎University, Abbasia square, Cairo, Egypt.‎

Email

omniamohamed@med.asu.edu.eg

City

cairo

Orcid

0000-0001-7060-6196

First Name

Azza

Last Name

Hassan

MiddleName

-

Affiliation

Department of Community, Environmental and Occupational Medicine, ‎Faculty of Medicine, Ain Shams University, Abbasia square, Cairo, Egypt.‎

Email

drazzahassan@gmail.com

City

-

Orcid

-

First Name

Mostafa

Last Name

Shamkh

MiddleName

-

Affiliation

Department of Tropical Medicine, Faculty of Medicine, Ain Shams University ‎Abbasia square, Cairo, Egypt.‎

Email

masrawy_ainshams@yahoo.com

City

cairo

Orcid

0000-0002-5521-858X

First Name

Mahmoud

Last Name

Mahmoud

MiddleName

-

Affiliation

Department of Chest Medicine, Faculty of Medicine, Ain Shams University, ‎Abbasia square, Cairo, Egypt.‎

Email

mahmoudtab@yahoo.com

City

-

Orcid

-

First Name

Ethar

Last Name

Badran

MiddleName

-

Affiliation

Department of Tropical Medicine, Faculty of Medicine, Ain Shams University ‎Abbasia square, Cairo, Egypt.‎

Email

ethar_badran@hotmail.com

City

-

Orcid

-

First Name

Hany

Last Name

Dabbous

MiddleName

-

Affiliation

Department of Tropical Medicine, Faculty of Medicine, Ain Shams University ‎Abbasia square, Cairo, Egypt.‎

Email

drhdabbous@gmail.com

City

cairo

Orcid

-

First Name

Osama

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine, Ain Shams University, ‎Abbasia square, Cairo, Egypt.‎

Email

dr.ossamaashrafahmed@gmail.com

City

-

Orcid

-

First Name

Rana

Last Name

Taha

MiddleName

-

Affiliation

Department of Geriatric Medicine and Gerontology, Faculty of Medicine, Ain ‎Shams University, Abbasia square, Cairo, Egypt.‎‎

Email

rmtaha86@gmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Sherief

MiddleName

-

Affiliation

Department of Tropical Medicine, Faculty of Medicine, Ain Shams University ‎Abbasia square, Cairo, Egypt.‎

Email

ahmedfouad85@live.com

City

-

Orcid

-

Volume

11

Article Issue

3

Related Issue

27232

Issue Date

2021-09-01

Receive Date

2021-04-16

Publish Date

2021-09-01

Page Start

306

Page End

313

Print ISSN

2090-7613

Online ISSN

2090-7184

Article File

AEJI_Volume 11_Issue 3_Pages 306-313.pdf

PDF . 556.8kB

Link

https://aeji.journals.ekb.eg/article_191420.html

Detail API

https://aeji.journals.ekb.eg/service?article_code=191420

Order

12

Type

Original Article

Type Code

616

Publication Type

Journal

Publication Title

Afro-Egyptian Journal of Infectious and Endemic Diseases

Publication Link

https://aeji.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023