Salama et al., in the current issue of Afro-Egypt J Infect Endem Dis published an interesting article focusing the prevalence of H pylori among patients with persistent itching. The authors reported a prevalence of H pylori among 130 out of 280 patients (46.4%) of persistent itching after exclusion of the common causes of itching. The authors reported 60% complete response defined as disappearance of itching after 2-weeks of H pylori treatment. Furthermore, 20% of patients reported partial improvement while 20% did not improve in comparison to 0% among the H pylori negative group treated with anti-histaminics. The authors reported also Ig E levels to be significantly higher among H pylori negative cases ruling out the allergic mechanism as a cause of skin affection in H pylori infected subjects.