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164557

Impact of Hepatitis C Viral Load in Chronic Kidney Disease Patients‎

Article

Last updated: 22 Jan 2023

Subjects

-

Tags

Infectious diseases

Abstract

Background and study aim: Chronic hepatitis C virus (HCV) infection is linked to chronic kidney disease (CKD) and hastens ‎its progress to end-stage renal disease (ESRD). Previous studies have examined the association ‎between chronic HCV and CKD and reported that HCV is correlated with proteinuria but not with ‎low estimated glomerular filtration rate (eGFR) depending mainly on anti-HCV antibodies to ‎diagnose chronic HCV infection. However, it is the HCV viral load to diagnose active HCV ‎infection. Therefore, our study aimed to elucidate the relationship between HCV viral load and ‎CKD‎.
Patients/Material and Method: It's a cross-sectional observational study that included 204 subjects that were classified into group ‎‎1 (90 chronic HCV patients without a history of chronic kidney disease) and group 2 (114 chronic ‎HCV patients with a history of chronic kidney disease). All subjects underwent full history taking, ‎medical examination, and laboratory investigation from May 2017 to May 2019‎.‎
Results: In CKD patients, HCV viral load was correlated with age, platelet count, serum creatinine, eGFR, ‎and serum bilirubin. Higher HCV viral load was one of the significant predictors of low eGFR in ‎patients with chronic HCV infection in addition to the female sex, older age, lower hemoglobin, ‎higher international normalized ratio, and higher alanine transaminase‎‎‎.
Conclusion: There is a strong positive association between HCV viral load and serum creatinine in CKD ‎patients. Higher HCV viral load carries a greater risk for lower eGFR in patients with chronic ‎HCV infection ‎‎.

DOI

10.21608/aeji.2021.53057.1121

Keywords

Bilirubin, Chronic hepatitis C, chronic kidney diseases, Glomerular Filtration Rate, Viral load

Authors

First Name

Walid

Last Name

Abdelhamid

MiddleName

Ahmed Ragab

Affiliation

Department of Internal Medicine, Faculty of Human Medicine, Zagazig University, Zagazig, Egypt

Email

waabdelhamid@medicine.zu.edu.eg

City

-

Orcid

-

First Name

Alsayed

Last Name

Alnahal

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Human Medicine, Zagazig University, Zagazig, Egypt

Email

wragab2009@gmail.com

City

-

Orcid

-

First Name

Ayman

Last Name

Zaki

MiddleName

-

Affiliation

Department of Gasteroenterology, Alahrar Teaching Hospital, Zagazig, Egypt

Email

wragab2009@yahoo.com

City

-

Orcid

-

First Name

Ayman

Last Name

Elsayed

MiddleName

Fathy

Affiliation

Department of Internal Medicine, Faculty of Human Medicine, Zagazig University, Zagazig, Egypt

Email

sniperblack2020@gmail.com

City

-

Orcid

-

Volume

11

Article Issue

2

Related Issue

25277

Issue Date

2021-06-01

Receive Date

2020-12-11

Publish Date

2021-06-01

Page Start

155

Page End

160

Print ISSN

2090-7613

Online ISSN

2090-7184

Link

https://aeji.journals.ekb.eg/article_164557.html

Detail API

https://aeji.journals.ekb.eg/service?article_code=164557

Order

8

Type

Original Article

Type Code

616

Publication Type

Journal

Publication Title

Afro-Egyptian Journal of Infectious and Endemic Diseases

Publication Link

https://aeji.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023