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112374

Influence of Cytokine Gene Polymorphisms on the Risk of Gastric Disorders in H. pylori Infected Patients

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Gastroenetrology

Abstract

Background and study aim: Helicobacter pylori (H. pylori) is a common organism in developing countries, it causes gastric disorders and cancer. Pathogenesis of these disorders involve cytokine gene polymorphisms that affect cytokine levels and clinical diseases. The aim of the study is to identify the relationship of IL-1β-511, IL-10-519 and TNF-α-308 polymorphisms to the risk of H. pylori infection and occurrence of gastric disorders.
Subjects and methods: IL-1β-511, IL-10-519 and TNF-α-308 polymorphisms were assessed using polymerase chain reaction (PCR) restriction fragment length polymorphism technique (RFLP) in 356 subjects classified according to H. pylori infection and gastric disorders.
Results: Carriers of T allele of IL-1β-511 and IL-10-519 had increased risk of H. pylori infection (OR:1.95, 95% CI:1.4-2.7, P Conclusion: This study revealed a significant association of the IL-1β -511C/T and IL-10-819C/T but not TNF-α-308 G/A polymorphisms with risk of Helicobacter pylori infection and different gastric diseases in Egyptian patients.

DOI

10.21608/aeji.2020.37775.1099

Keywords

Helicobacter pylori, IL-1β-511, IL-10-519, TNF-α-308, gastric diseases

Authors

First Name

Heba

Last Name

Pasha

MiddleName

F

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Email

hebapasha@yahoo.com

City

Zagazig

Orcid

-

First Name

Enas

Last Name

Tantawy

MiddleName

A

Affiliation

Department of Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Email

enasatantawy@gmail.com

City

Zagazig

Orcid

-

First Name

Mohamed

Last Name

Radwan

MiddleName

I

Affiliation

Department of Tropical Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Email

drmmagdy@gmail.com

City

-

Orcid

-

First Name

Hoda

Last Name

Hagrass

MiddleName

A

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt;Department of Pathology, College of Medicine, University of Arkansas for Medical Science, USA.

Email

hhagrass@uams.edu

City

-

Orcid

0000-0003-2578-4596

First Name

Nagla

Last Name

Abd Al-Monem

MiddleName

-

Affiliation

Department of Tropical Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Email

-

City

-

Orcid

-

First Name

Amira

Last Name

AL-Karamany

MiddleName

S

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Email

aselkaramany@zu.edu.eg

City

-

Orcid

-

Volume

10

Article Issue

4

Related Issue

18970

Issue Date

2020-12-01

Receive Date

2020-08-04

Publish Date

2020-12-01

Page Start

397

Page End

406

Print ISSN

2090-7613

Online ISSN

2090-7184

Article File

AEJI_Volume 10_Issue 4_Pages 397-406.pdf

PDF . 557.5kB

Link

https://aeji.journals.ekb.eg/article_112374.html

Detail API

https://aeji.journals.ekb.eg/service?article_code=112374

Order

9

Type

Original Article

Type Code

616

Publication Type

Journal

Publication Title

Afro-Egyptian Journal of Infectious and Endemic Diseases

Publication Link

https://aeji.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023