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65485

Ascitic non-HDL-C/HDL-C ratio:a novel prognostic marker in liver cirrhosis

Article

Last updated: 22 Jan 2023

Subjects

-

Tags

Hepatology

Abstract

Background and study aim: Laboratory tests were developed on ascitic fluid for assessing causes, mechanisms, and prognosis of the diseases. This study aimed to evaluate the prognostic value of ascitic lipids in cirrhosis with special consideration to the non-high-density lipoprotein cholesterol (HDL-C) and its related ratios.
Methods: This cross-sectional study included 120 cirrhotic patients with ascites. Ascitic fluid analysis for lipid contents and calculations of ratios were done. Ascitic lipid contents and ratios are used to assess liver disease severity and predict the mortality in different Child-Pugh groups.
Results: Regarding Child-Pugh score, ascitic cholesterol, and HDL-C showed significantly higher levels in group C when compared to groups A and B.  Ascitic non-HDL-C and ascitic non-HDL-C/ HDL-C ratio had a statistically significant increasing trend among Child-Pugh groups. Serum-ascites cholesterol gradient showed no significant difference among Child-Pugh groups (p>0.05). Ascitic non-HDL-C/ HDL-C ratio had the highest positive linear correlation with cirrhosis severity scores (p<0.0001). High ascitic non-HDL-C/ HDL-C ratio patients had a higher mortality rate when compared to those with a lower ratio (38.5% versus 9.5%).
Conclusion: Ascitic non-HDL-C/HDL-C ratio was more beneficial than non-HDL-C in cirrhosis severity prediction. Also, it could predict the cirrhotic patients' survival. So, Ascitic non-HDL-C/HDL-C ratio seems to be an excellent prognostic marker for cirrhosis.

DOI

10.21608/aeji.2019.18845.1039

Keywords

ascites, Lipid, Liver cirrhosis, Non-HDL

Authors

First Name

Marwa

Last Name

Esawy

MiddleName

M

Affiliation

Clinical Pathology Department, Faculty of Medicine, Zagazig University, Egypt

Email

dr.marwaesawy@ymail.com

City

-

Orcid

-

First Name

Marwa

Last Name

Shabana

MiddleName

A

Affiliation

Clinical Pathology Department, Faculty of Medicine, Zagazig University, Egypt

Email

marwa_shabana@yahoo.com

City

-

Orcid

-

First Name

Elsayed

Last Name

Abd elbaser

MiddleName

S

Affiliation

Tropical Medicine Department, Faculty of Medicine, Zagazig University, Egypt

Email

dr.sayedsaad79@gmail.com

City

Zagazig

Orcid

0000-0001-9492-9707

First Name

Hany

Last Name

Elsadek

MiddleName

M

Affiliation

Internal Medicine Department ,Faculty of Medicine , Zagazig University,Egypt

Email

hanyelsadek75@yahoo.com

City

-

Orcid

-

Volume

10

Article Issue

1

Related Issue

11235

Issue Date

2020-03-01

Receive Date

2019-10-30

Publish Date

2020-03-01

Page Start

1

Page End

9

Print ISSN

2090-7613

Online ISSN

2090-7184

Link

https://aeji.journals.ekb.eg/article_65485.html

Detail API

https://aeji.journals.ekb.eg/service?article_code=65485

Order

1

Type

Original Article

Type Code

616

Publication Type

Journal

Publication Title

Afro-Egyptian Journal of Infectious and Endemic Diseases

Publication Link

https://aeji.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023