Background and study aim: The association between H. pylori infection and cirrhosis in patients with hepatitis C virus has been documented in different parts of the world. Eradication treatment may prove beneficial in those patients with chronic hepatitis C. The aim of the present study was to study H. pylori infection in patients with portal hypertensive gastropathy. Patients and Methods: This study was conducted on Session [CurrentTestPartID] patients; 45 patients with portal hypertensive gastropathy (Group A). In addition to 15 patients with chronic gastritis without portal hypertension (Group B). All patients were subjected to full history tacking and complete physical examination. Routine laboratory investigation including, CBC, PT, PC, INR, SGOT, SGPT, S. Albumin, S. Bilirubin. Radiological examination including abdominal ultrasound, and Doppler study for Portal vein. Upper GIT endoscopy, and biopsies from the antrum. Histopathological examination of the biopsies for assessment of congestive gastropathy and H. pylori infestation if present. Results: This study demonstrated that the Session [CurrentTestPartID]% of patients of group A and 66% of patients of group B have H. pylori infection. There was no predilection for H. pylori infections in patients with PHG than those in patients with gastritis. In group A, 53% of patients with varices had H. pylori infection while 47% did not have H. pylori infection. Also, 76% of the non H. pylori patients had esophageal varices while Session [UserIDID]% of patients with non H. pylori subgroup had no varices. Additionally, patients of group A with mild PHG and H pylori constituted 26.5%, those with moderate PHG and H pylori constituted 47% while patients with severe PHG and H pylori constituted 26.5%. Conclusion: This study demonstrated that there is no predilection concerning the presence of H pylori infection in patients with PHG and there is no relation between the degree of PHG and the presence of H pylori infection.