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17792

Role of Transient Elastography in Early Detection of HCC in Cirrhotic Patients

Article

Last updated: 22 Jan 2023

Subjects

-

Tags

Hepatology

Abstract

Background and study aim: Hepatocellular carcinoma (HCC) is common primary malignancy of the liver and one of the most frequent causes of death in patients with liver cirrhosis. Nowadays, liver stiffness measured non-invasively by transient elastography has been reported to be well correlated with histologically assessed liver fibrosis stageThe degree of liver fibrosis is the strongest indicator of risk for HCC development, that's why liver stiffness measured by transient elastography is helpful in demarcating patients at a high risk for HCC, who need frequent check-up by imaging examinations.The aim of this study was to study the role of ultrasound elastography (FibroScan) in early detection of hepatocellular carcinoma in cirrhotic patients as well as verifying whether ultrasound elastography (Fibro-Scan), could be used as a tool for identifying cirrhotic patients who are at high risk of developing HCC.
Patients and Methods: This study included 100 patients; 50 with HCC and 50 cirrhotics without evidence of HCC . For all groups, clinical data and image findings were studied. Tumour characteristics were assessed including size, number and site. Tumor staging was done using Okuda, CLIP, VISUM and Tokyo staging systems. Transient elastography was done for all patients and the results were expressed in kilopascal.
Results: Liver stiffness was significantly higher in HCC patients compared to cirrhotic patients. The sensitivity and specificity in diagnosis of HCC were 72% and 84% respectively at cut-off of 30.4 kpa with 91.1% accuracy. Fibroscan has a positive significant correlation with tumour size (P<0.001), Child–Pugh (P<0.001), Okuda classification (P<0.001), CLIP staging (P<0.001) and Tokyo classification (P<0.001) among HCC patients. It was found that likelihood of HCC risk was correlated with increase of liver stiffness. At liver stiffness of 25-30 kpa the probability of HCC is 91% so, these patients should undergo close follow up. Patients with stiffness ≥30 kpa had HCC.
Conclusion: Fibroscan could be used for early detection of HCC in cirrhotic patients and determining the patients who are at high risk for developing HCC.
 

DOI

10.21608/aeji.2017.17792

Keywords

Hepatocellular carcinoma, Transient elastography, Liver Stiffness

Authors

First Name

Abdel Ghani

Last Name

Badran

MiddleName

Atef

Affiliation

Liver and GIT center,Damas, Meet Ghamr,Dakahlia,Egypt

Email

prof_abdo1985@yahoo.com

City

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Orcid

-

First Name

Naglaa

Last Name

El-Tokhy

MiddleName

Ramadan

Affiliation

GIT, Hepatology and infectious DiseasesDepartment , Faculty of Medicine , Benha University

Email

-

City

-

Orcid

-

First Name

Seham

Last Name

Seif

MiddleName

Mohamad

Affiliation

Internal Medicine (GIT and Hepatology)Department , Faculty of Medicine, Mansoura University

Email

-

City

-

Orcid

-

First Name

Hossam

Last Name

Baioumy

MiddleName

Amin

Affiliation

GIT, Hepatology and infectious DiseasesDepartment , Faculty of Medicine , Benha University

Email

-

City

-

Orcid

-

Volume

7

Article Issue

3

Related Issue

3472

Issue Date

2017-09-01

Receive Date

2017-09-04

Publish Date

2017-09-25

Page Start

159

Page End

168

Print ISSN

2090-7613

Online ISSN

2090-7184

Link

https://aeji.journals.ekb.eg/article_17792.html

Detail API

https://aeji.journals.ekb.eg/service?article_code=17792

Order

10

Type

Original Article

Type Code

616

Publication Type

Journal

Publication Title

Afro-Egyptian Journal of Infectious and Endemic Diseases

Publication Link

https://aeji.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023