Background and study aim:Endoscopes are complex and reusable devices. Understanding infection control in the context of endoscopy is important in reducing the transmission of infection. This study aims to evaluate the effect of an educational program on improving nurse's knowledge and practice regarding infection control in endoscopy unit at Zagzig  University Hospital.
Subjects and methods: A quasi experimental research design was used.  The study was conducted in the Endoscopy Unit at Zagazig University Hospitals. The study samples were all available endoscopy nursing staff . First tool was Questionnaire sheet, to assess nurses' knowledge. The second tool was observational checklist to assess nurses' practice.
Results:this study revealed that two third of nurses were in the age group of more than 40 years with mean age 42.2 ± 8.4 years and the majority of the sample had more than 10 years experience. There was improvement in total level of nurses'knowledge and practice regarding infection control with highly statistically significant difference between pre- post and pre-follow up program phase as regarding to infection control.
Conclusion:The implementation of health educational program had improved nurse's knowledge and practice regarding endoscopy infection.
Recommendations: Continuous educational and infection control training programs are recommended in endoscopy units. So incorporation of such interventions apply in all endoscope unite all over Egypt.