Background: The chronic inflammatory condition known as alopecia areata causes non-cicatricial hair loss. Ablative Fractional laser treatments as well as other laser therapies with various wave lengths have been used to treat AA. Objective: The aim of the current review is to assess the efficacy and safety profile of fractional carbon dioxide (CO2) treatment in alopecia areata. Development: CO2 lasers come in two varieties: nonfractionated and fractionated (both ablative and nonablative). In comparison to nonfractionated lasers, fractionated ablative and nonablative lasers offer a better safety profile. The two operating modes for this kind of laser are continuous and pulsed. Utilizing the continuous wave style consumes significantly more energy. Either a continuous wave or an intermittent wave can be selected for the pulse mode. The ultrapulsed mode, which has also enabled therapy with the greatest power, the least thermal damage, and hence the fewest side effects, is a final option. Conclusion: Alopecia areata may respond well to treatment with fractional CO2 laser.