Background: Following primary percutaneous coronary intervention (PCI), contrast-induced nephropathy (CIN) is linked to higher mortality and morbidity. The monocyte to high density lipoprotein cholesterol ratio (MHR), which has been used as a novel predictive marker in patients with cardiovascular and renal disorders, has been linked in several studies to a number of negative cardiovascular outcomes.
Objective: The current study was conducted to explore correlation between monocyte to HDL ratio and CIN after primary PCI in patients presented with ST-segment Elevation Myocardial Infarction (STEMI).
Patients and methods: A total of 80 patients with acute STEMI were included. Patients were differentiated into two groups according to development of contrast induced nephropathy; Group (A) Patients who developed contrast induced nephropathy, and Group (B) Patients did not develop contrast induced nephropathy. CIN was defined as either a 25% increase in serum creatinine from baseline or 0.5 mg/dL increase in absolute value, within 48-72 h of intravenous administration of contrast medium.
Results: A total of 16 (20%) patients developed CIN. MHR was significantly higher in CIN positive group [mean 0.0202 (range 0.009-0.0633) 10⁸/mg] than non-CIN group [mean 0.0129 (range 0.0031-0.0307) 10⁸/mg] with P-value = 0.003. MHR was also significantly correlated with creatinine levels 48 hours after PCI (r_s: 0.322, P: 0.004). ROC statistical analysis showed that MHR >0.0131 was the best cutoff values for predicting contrast induced nephropathy with sensitivity 76% and specificity 71.2%.
Conclusion: Higher MHR levels may predict CIN development after primary PCI in STEMIpatients.