Background: Bariatric surgery interferes with food absorption, which may cause deficiencies in certain elements and complications. Copper deficiency after bariatric surgeries may be misdiagnosed, which may cause serious diseases. Objective: The current study aimed to investigate the significance of serum copper level in the early detection of anemia related to bariatric surgery. Patients and methods: This study included 50 participants from both sexes divided into 25 anemic patients after bariatric surgery and 25 healthy individuals. Full history taking and complete clinical examination were performed for all participants. Laboratory investigations included hemoglobin (Hb) measurement, serum copper measurement, and iron parameters including serum iron, ferritin, total iron binding capacity (TIBC), and transferrin saturation.        Results: There was a highly statistically significant decrease in Hb, serum iron, copper, and ferritin levels after bariatric surgery while transferrin level and TIBC were significantly higher in cases than their controls (P <0.001 for each), while transferrin level and TIBC were significantly higher after bariatric surgery compared to controls (P <0.001 for each). There were highly statistically significant positive correlations between copper level and each of serum hemoglobin (r= 0.726, P=0.03) and iron level (r=0.986, P <0.001), while there were significant negative correlations between copper level and each of transferrin level (r=-0.617, P=0.005) and TIBC (r=-0.520, P=0.008). Conclusion: Copper deficiency after bariatric surgery is associated with iron deficiency anemia. So, copper supplement in addition to iron supplement after bariatric surgery is necessary to avoid the occurrence of anemia.