Background:  Chrysin is a flavone that occurs naturally in plants and possesses antioxidant and anti-inflammatory effects. Objective: This study was carried out to examine the effect of chrysin on the adrenal cortex of maternally treated rat fetuses. Material and methods: Twelve pregnant rats were assigned into two groups (6 rats each). The first group acted as a control and received a vehicle 1% w/v Tween 80 (the drug's solvent) (GDs 7-14), whereas rats of the second group were treated orally with chrysin (50 mg/kg body weight/day) daily from day 7 till day 14 of gestation. Animals were sacrificed, and samples of the adrenal glands were taken, processed, and prepared for the histological and ultrastructural examination. Results: The three cortical zones, Zone glomerulosa, Zone fasciculata, and Zone reticularis in the cells of the adrenal cortex sections from maternally treated rat foetuses showed cytoplasmic vacuolation. Some of these cells' nuclei showed indications of karyolysis. Cortical cells had clear alterations at the ultrastructural level, including cavitated and deformed mitochondria as well as dilated smooth and rough endoplasmic reticular membranes. Accumulation of lipid droplets and lysosomes was seen in the vacuolated cytoplasm. These cells' nuclei had karyolysis visible. Conclusion: It appears that oral administration of chrysin caused damaging effects on adrenocortical cells of maternally treated rat fetuses. Therefore, it should be taken into mind and viewed with great worry that chrysin, although one of the flavonoids, should be utilized with caution during pregnancy.