Background: The severe acute respiratory syndrome (SARS), the Middle East respiratory syndrome, and the common cold are all diseases that can be brought on by the coronavirus family of viruses (MERS). A disease epidemic that began in China was linked to a novel coronavirus in 2019. A person's quality of life is impacted by Corona Virus Disease 2019 (COVID-19), which also raises the rate of morbidity and mortality. The chance of developing a major disease from COVID-19 rises with age in older adults. A major sickness may be more likely to strike those who already have underlying medical issues. Objectives: The purpose of the current study is to objectively evaluate the effect of physiotherapy therapy on COVID-19 patients. Patients and methods: A total of 60 COVID-19 patients were included, with ages ranging from 46–55 years, and were divided into two age-and-sex-matched groups. They were divided into two groups; A and B (intervention and control), of an equal number of patients, each 30. Both groups received their COVID-19 medical treatment. In addition, group A received a physiotherapy protocol, 3 times per week for 2 weeks as a total period of treatment. Vital signs and blood gases were measured before and after the study. Results: There was a statistically significantly higher post-intervention O2 saturation and PaO2 in group A vs. group B, and a statistically significantly higher post-intervention PaCO2 in group B vs. group A. There was no statistically significant difference in all other parameters (systolic blood pressure, diastolic blood pressure, HCO3, PH, heart rate, or respiratory rate). Conclusion: For COVID-19 patients, the physiotherapy therapy PT protocol is an effective, noninvasive, and safe method.