Background: Motor deficits are common and extensive in neurodevelopmental disorders, autism spectrum disorder in particular (ASD). Additionally, motor deficiencies are probably the cause of difficulties with social communication, which may be the first sign of atypical development in ASD. Objective: The purpose of this study was to examine the degree of mobility impairment in kids with autism spectrum disorders (ASD). Patients and methods: A cross-sectional study was carried out in Assiut University Child Hospital. All children with autism from the age of 3 years to 18 years in Neurological Outpatient Clinic in Assiut University Pediatric Hospital diagnosed using the Movement Assessment Battery for Children (M-ABC) were included. Results: There was significant difference between improvement after physiotherapy (Not yet, No improvement and Improved) and Medical treatment (Antipsychotics). There was highly significant difference between improvement after physiotherapy (Not yet, no improvement and improved) and compliance, and there is no significant difference between improvement after physiotherapy (Not yet, no improvement and improved) and outcome. Conclusion: The physical health of children with ASD improved as a result of the physiotherapy sessions, including agility, coordination, usable skills, and powerful, quick legs. Additionally, it became simpler to exercise in a group, at home, or in private sessions with a professional.