Background: P. acnes is a pleomorphic rod that is aerotolerant, anaerobic, Gram positive, non-spore-forming, and a member of the class Propionibacteriales in the phylum Actinobacteria. Antibiotic therapy for acne is widely recognized as an effective strategy for managing this common skin condition. P. acnes skin colonization can also lead to Pseudomonas folliculitis, a Gram-negative folliculitis. By stimulating a regional upsurge in keratinocyte autophagic activity, P. acnes strains may play a role in antimicrobial defence pathways. Objective: This review article aimed to assess the antimicrobial resistance during acne treatment. Methods: We searched PubMed, Google Scholar, and Science Direct for information on Antimicrobial Resistance with Acne Treatment. However, only the most current or comprehensive study from January 2000 to May 2021 was considered. The authors also assessed references from pertinent literature. Documents in languages other than English have been disregarded since there aren't enough resources for translation. Unpublished manuscripts, oral presentations, conference abstracts, and dissertations were examples of papers that weren't considered to be serious scientific research. Conclusion: Antibiotic resistance in P. acnes could compromise the success of acne treatments. Extensive use of antibiotics to treat acne may have consequences in other illnesses where P. acnes may be the etiological culprit. Recent research has shown that the phylotype IA1 is the most common among resistant strains. Variants of this genotype that are resistant to antibiotics have been discovered all over the world, including on the skin of otherwise healthy people.