Background: Lyophilized platelet-rich plasma (L-RPR) is considered a simple and effective comparable method to fresh preparations of platelet-rich plasma (PRP). It is prepared using platelets concentration derived from different donors. It is ubiquitously available and enables medical professionals to inject a specific volume of growth factors. Objective: The aim of the current study is to assess the effect of L-PRP in treating superficial wrinkles. Patients and methods: The present one-arm clinical trial was performed on 20 adult females (age range between 30 and 50 years old) with Type I and II superficial wrinkles (Glogau classification). The entire face was injected with a 2 cm reconstituted vial of sterilized L-PRP (L-GF^®) for 3 treatment sessions at 2-week intervals. The evaluation was done before each treatment session and 2 weeks after the last session with 8 megapixels and Antera 3D^® cameras. The wrinkles indentation index, the texture (roughness) score, the average melanin level, and the melanin variation were calculated. Results: The mean duration of wrinkles was 5.8 (SD 2.9) with a range of 2-12 years. Most cases (95%) had skin type III and Glogau classification type II (75%). A statistically significant difference was found before and after treatment in the average melanin level using Antera 3D^® camera assessment. However, no significant difference was found before and after treatment regarding the roughness score, melanin variation level, and wrinkle indentation index.Treatment was well tolerated with minimal local side effects. Conclusion: L-PRP is a safe, simple, and cost-effective treatment modality for aging-related hyperpigmentation.