Background: Early-stage oral cancers are usually treated with surgical resection and in most of cases the resulting defects are too large to be primarily reconstructed. There are many modalities of reconstruction as nasolabial flap, buccal bad of fat, polyglycolic acid sheets. Objective: This work aimed to evaluate the reconstruction of oral mucosal defects using either polyglycolic acid (PGA) sheet or nasolabial flap. Material and Methods: 51 patients of them 26 were reconstructed using (PGA) sheet, and 25 using nasolabial flap retrospectively. The tumors' location, perioperative situation, postoperative aesthetic and functional results were assessed.  Results: There was no significant difference between the 2 groups regarding the early start of oral feeding or hospitalization time. While, the PGA group had significant shorter operative time. In cases with exposed bone surface, the PGA sheet was more feasible for reconstruction. There was no significant difference between the 2 groups in speech intelligibility in lingual cases. In buccal reconstruction the PGA sheets were more suitable for larger defects. Conclusion: The optimal choice of nasolabial flap or PGA sheet depends on tumor location, mucosal defect size, the general condition of the patient and tolerability for surgery.