Background: Dental enamel was treated with laser irradiation and fluoride compounds as a method to enhance fluoride absorption by the enamel, which resulted in a rise in the mineral content of the enamel and a significant boost in its resistance to acid demineralization. Objective: The purpose of this research was to look into the effects of Titanium tetra Fluoride (TiF4) with or without diode laser on the demineralized enamel. Material and methods: The sample consisted of 65 premolars teeth: 5 teeth  remained sound for energy dispersive spectroscopy (EDS) analysis where 60 teeth were divided into 6 groups by treatment (N=10): (1) control negative (deionized water), (2) control positive (acidulated phosphate fluoride gel (APF)), (3) 6% Titanium tetra fluoride (TiF4) solution, (4) diode laser (810 nm, 0.5W, 60 s), (5) Laser then TiF4, and (6) Tif4 then Laser. Microhardness was measured before and after demineralization then after treatments. Five samples from each group were selected randomly for EDS analysis. Results: Microhardness increased significantly after all treatments (p < /em><0.05). Results revealed a significant difference for all treatment groups (p < /em><0.05). EDS analysis revealed that fluoride content was greater in 6%TIF4 then Tif4 with Laser groups, while the calcium content was greater in control positive followed by TiF4 groups. Conclusion: TiF4 alone or in combination with laser enhancing demineralized enamel microhardness and fluoride content. Diode laser before or after TiF4 had minimal extra impact on remineralization.