Background: One of the PGF2 α analogues, latanoprost solution is applied topically to the eye to lower intraocular pressure and treat glaucoma. Latanoprost has been examined for the treatment of cutaneous hypopigmentation since evidence of its periocular and pigmentation adverse effects emerged. It has been found to be useful, especially when combined with other medications. It has been reported that topical latanoprost is effective as a monotherapy for vitiligo. Objective: This study aimed to assess the possible role of latanoprost in management of vitiligo. Methods: We searched PubMed, Google Scholar, and Science Direct for information on vitiligo with latanoprost. However, only the most current or comprehensive study from November 2001 to May 2021 was considered. The authors also assessed references from pertinent literature. Documents in languages other than English have been disregarded since there aren't enough resources for translation. Unpublished manuscripts, oral presentations, conference abstracts, and dissertations were examples of papers that weren't considered to be serious scientific research. Conclusion: According to some studies, using latanoprost in conjunction with other treatments for vitiligo is more beneficial than using latanoprost alone.