Background: laser acupuncture due to its anti-inflammatory and immunocorrection action has great role in improving immunity parameters (neutrophils and total lymphocytes) and accelerate wound healing in patients with depressed immune system after burn.
Aim: This study aimed to investigate the response of immune system and wound healing of laser puncture in burned patients through comparing the impact of laser puncture and routine medical treatment on treatment of burned patients.  
Subjects and Methods: After one week of burn injury, sixty patients (31 males and 29 females) suffering from thermal burn injury (second degree) were randomized into two groups: laser puncture group (A) (n = 30) as well as control group (B) (n = 30). The intervention was performed 3 sessions each week for two months. Wound measurement – working out surface area in cm² and complete blood cell counts (Neutrophils, total lymphocytes) were evaluated pre- and post-intervention.
Results: In groups A and B, there was a significant decrease in wound surface area and a substantial increase in lymphocytes as well as neutrophils post-treatment compared to pre-treatment (p > 0.001).
Conclusions: laser puncture is an effective technique to increase the immunity parameters and wound healing in burned patients.