Background:  Quality of life (QoL) in rheumatoid arthritis patients may be greatly affected by their personality, which shape their perception of illness, their attitude, and behavior. Up to our knowledge, none has discussed personality traits in Egyptian RA patients. Objectives: To study personality traits in Egyptian RA patients and its impact on health-related quality of life together with its relation to severity of illness. Methods:A cross-sectional study was conducted on 150 Rheumatoid arthritis female patients and 50 healthy voluntaries. All participants completed the following: socio-demographics, SF-36, Eysenck personality questionnaire, hospital anxiety and depression scale, DAS-28, Pain VAS, and laboratory investigations. Results:  Neuroticism traits were substantially more in RA patients and significantly correlated to most of measured variables. QoL deteriorated in RA patients. Pain severity (coefficient B= -0.31, p 0.002) and depression severity (coefficient B= -0.25, p 0.01) were an independent negative predictor of life quality related to physical health, followed by higher disease activity (coefficient B= -0.20, p 0.02), disease span (coefficient B= -0.19, p 0.02). Depression was an independent negative predictor of quality of life related to mental health (coefficient B=-0.42, p < 0.001) followed by anxiety (coefficient B=-0.38, p < 0.001), then disease span (coefficient B=-0.17, p 0.03) and Pain severity (coefficient B=-0.34, p0.04)  Conclusion: Personality traits specially neuroticism was significantly correlated with most of measured variables and affect QoL in Egyptian RA patients, indirectly.