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279660

The X­Ray Repair Cross Complementing 1(XRCC1) Rs25487 Variation and Susceptibility to Cirrhosis in Patients with Chronic Hepatitis C Virus

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Last updated: 03 Jan 2025

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Abstract

Background: Around 130–170 million individuals are thought to be affected with the hepatitis C virus (HCV), which is a viral pandemic and the leading cause of persistent liver illness. The frequency of HCV infections is greatest in Egypt, where more than 10% of the general population is affected. Objective: The purpose of the current study was to confirm any potential associations between cirrhosis and the XRCC1 rs25487 variant in chronic HCV patients. Patients and methods: A fibroscan was conducted on 80 HCV +ve patients and 40 control participants for a total of 120 people to determine the extent of hepatic fibrosis. Real-time PCR was used to examine the SNP genotyping in the XRCC1 gene (rs25487). Results: There were no substantial variation in the prevalence of different genotypes in XRCC1 A > G (GG and AG) between non cirrhotic and cirrhotic in chronic HCV Egyptian patients. Conclusion: By comparing the incidence of the various genotypes (AA, AG, and GG) in the analyzed groups, no clear pattern of relationship could be seen (p=0.225). (P = 0.410) There was no distinguishable pattern of connection between the AA genotype and the other genotypes (GG and AG). Comparing the frequencies of the two alleles (A and G alleles) in the three groups under study revealed no evidence of a connection.  

DOI

10.21608/ejhm.2023.279660

Keywords

X­ray repair, rs25487 Variation, Cirrhosis, Chronic hepatitis C virus, Case control study, Cairo University

Authors

First Name

Dalia

Last Name

Hamed

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Orcid

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First Name

Badawy

Last Name

El Kholy

MiddleName

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Orcid

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First Name

Hadeel Gamal

Last Name

El Deen

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First Name

Samar Mahmoud Mohammed

Last Name

Momen

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Affiliation

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First Name

Nora Mahmoud

Last Name

Selim

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Affiliation

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Email

nora.selim@hotmail.com

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Orcid

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Volume

90

Article Issue

1

Related Issue

38787

Issue Date

2023-01-01

Receive Date

2023-01-10

Publish Date

2023-01-01

Page Start

453

Page End

458

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_279660.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=279660

Order

63

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

The X­Ray Repair Cross Complementing 1(XRCC1) Rs25487 Variation and Susceptibility to Cirrhosis in Patients with Chronic Hepatitis C Virus

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Article

Created At

22 Jan 2023