Background: Psoriasis is a long lasting immune-mediated disease that has a significant ferocious effect on quality of life (QOL). It is often accompanied with social stigmatization, physical disability and psychological disorders that may reach to suicidal ideation. All these effects of psoriasis have a significant negative impact at patients' work productivity. Nevertheless, the effects of psoriasis on work-related factors have not been extensively studied. Objective: The aim of the current study is to assess the relationship between the severity of psoriasis, dermatology life quality index and work limitation among employed psoriatic patients. Patients and methods: A cross-sectional study was conducted at Benha University Hospital Dermatology Clinic from 1^st August 2022 till the end of October 2022. The study included 180 of psoriasis patients using an interview questionnaire incorporating the Dermatology Life Quality Index (DLQI) and Work limitation questionnaire (WLQ). An assessment of the disease severity was carried out using the Psoriasis Area Severity Index (PASI). Results: The majority of studied group were males (64.4%) with a median (IQR) age 45 (40-52) years old. Their median (IQR) disease duration was 12 years. About 48.9% of the studied patients have degree PASI score. DLQI and WLQ score significantly increased among studied patients have severe PASI grade [median 26 (IQR 23-27) and median 65 (IQR 50-75), respectively]. There were highly significant positive correlations between DLQI and WLQ score, age and disease duration among the studied patients. Conclusion: Psoriasis has a great impact on the workers, the organization and the society as a whole. So measures for good psoriasis management are recommended.