Background: COVID-19 illness is a major problem that has the possibility of resulting in morbidity and death. Research on harmful outcomes of SARS-CoV-2 on the cardiovascular and circulatory systems have been documented, complicating the therapy of these patients even more. Objective: The purpose of this research was to evaluate the safety and consequences of heart surgery in COVID-19 previously infected patients. Patients and Methods: A retrospective observational study on patients receiving open heart surgery was carried out at Elkasr Elaini Medical Center, Cardiothoracic Surgery Department, Cairo University. Patients who tested positive for COVID-19 before surgery were detected and included. Data from patient files were examined and evaluated in real time, complemented by telephone following discharge. Results: Nineteen positive cases of COVID-19 underwent open heart surgery; June 2020-September 2021in our center. Mean age of patients was 58±9 years old. Mean time from confirmed COVID-19 with positive swab using PCR to surgery was 45±15 days. The vast majority of patients (94.7%) were extubated within 24 hours following operation. Acute renal failure developed in 10.5% of the patients, and one patient suffered severe heart failure, seven patients (63.8%) required less than or equal to seven days in the hospital, whereas 11 patients (57.9%) required between eight and fourteen days, one patient required more than 14 days. There were 2 mortalities one was covid related while the other died from severe heart failure refractory to treatment. Conclusion: After a period of convalescence, cardiac operation might be conducted successfully in individuals who suffered from COVID-19 illness before undergoing surgery.