Background: Ultrasonography is considered as the primary imaging technique used for identification, diagnosis, treatment, and follow-up of lesions affecting the major salivary gland. Both grey scale and color Doppler ultrasound maneuvers are frequently used for assessment of various salivary gland infirmities. As well, it is used for classification of the major salivary gland pathologies. This study aimed to assess the validity of ultrasound in the diagnosis and prediction of the parotid and submandibular gland lesions. Patients and Methods: Sixty-nine cases with salivary gland masses were investigated via using grey scale, color Doppler and spectral Doppler. Grey scale was used for the morphological features of each tumor; color Doppler for the blood vessel distribution and frequency; and spectral Doppler for determination of the peak systolic velocity, resistive index and pulsatility index. Postoperative through histopathological examination was carried out for all cases after excision of mass. Results: According to the histopathological examination, 28 of 69 (40.6%) lesions were identified as benign, 13 of 69 (18.8%) as malignant, and 28 of 69 (40.6%) as inflammatory. Color Doppler revealed that malignant lesions had significantly higher grade of vascularity and a mixed “scattered" pattern of distribution. Using spectral Doppler, malignant masses had significantly higher Doppler ultrasound wave forms. Grey scale sonar showed that the rate of ill-defined borders, heterogeneous structure, and irregular shape was significantly higher in Malignant than benign tumors. Conclusions: Adding Doppler ultrasound (color and pulse wave) may grant better diagnosis for malignant salivary gland tumors.