Background: Cellulite is a complicated condition that involves alterations in the adipocytes, extracellular matrix, lymphatic system, and microcirculation. Aim of study: This study aimed to assess impact of monopolar radiofrequency (MRF) on cellulite of thighs in obese women. Patients and Methods: Thirty women complaining from cellulite in thighs, their ages ranged from 25-35 yrs. and BMI ranged from 25-35 kg/m². They were randomly assigned into control group (A) (n=15) proceeded low caloric diet (1200 kcal/day) for 5 weeks and study group (B) (n=15) proceeded the same diet in addition to MRF 3 times per week for 5 weeks. Evaluating weight by a weight- height scale, calculating body mass index (BMI), and determining grade of cellulite by Nurenberger-Muller scale, thigh circumference by tape measurement and subcutaneous fat thickness by ultrasonography. All of which were done before and after 5 weeks of treatment. Results: Comparing both groups after treatment showed significant improvements in all evaluated measures in favor of study group (B) (p < 0.05). Conclusion: Monopolar radiofrequency improves significantly cellulite of the thighs in obese women.