Background: Despite numerous recent developments in an evidence-based approach to Premature Rupture of Membranes (PPROM) management, there is no widely accepted set of therapeutic techniques. A model for predicting intra-amniotic inflammatory markers is required to prevent a negative neonatal outcome in pregnant women with PPROM. This model has the potential to enhance pregnancy management and parental counselling for at-risk women. This is supported by the prevalence of bacterial infection in premature birth and its association with intra-amniotic inflammation. Objective: The aim of the current study is to determine whether serum interleukine-6 concentrations predict impeding preterm delivery. Patients and methods: This case control study included women with a singleton pregnancy, who were admitted to Maternity Hospital and diagnosed with PROM at gestational age from 24 week to 36 weeks. Participants were divided into Control Group < /em> consisted of 30 women who had at least one normal pregnancy without history of PROM, abortion, still birth, or preterm delivery and Study Group consisted of 30 women at high risk of preterm labor with history of at least one preterm labor or mid-trimester abortion. IL-6 was measured in studied groups. Results: For diagnosis of preterm labor (PTL), the best cutoff point of IL-6 was ≥64.5, with sensitivity 80%, specificity 100% and accuracy 90%. Area under the curve was statistically significant. Conclusion: With strong sensitivity and specificity, maternal blood IL-6 can be utilized as a biomarker to identify impending infection in PPROM patients. This information can also help the doctor modify treatment plans to optimize feto-maternal outcomes.