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277126

Potential Ameliorative Effect of Crude Honeybee on Monosodium Glutamate Induced Nephrotoxicity to Male Rats

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Last updated: 03 Jan 2025

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Abstract

Background: Monosodium glutamate (MSG) is a commercial food improver and is widely marketed as a flavor enhancer. It is now utilized in many processed foods and by most fast-food chains. Honey is a potent antioxidant that acts in the body against many diseases. Objective: The aim of the current study is to investigate honey's ameliorative effect on kidney damage initiated by monosodium glutamate in adult male rats. Moreover, different polyphenolic compounds in the crude honey were evaluated. Material and methods: Forty adult male albino rats were equally divided into four groups (N=6): The Control group was administered 1 mL of saline daily orally, the MSG group (30 g/kg on diet), the Honey group (2.5 g/kg body weight/day, orally) and Honey/MSG group as the previous for one month. Results: Urea, creatinine, and uric acid were significantly increased in the MSG group and decreased in the honey/MSG group compared to the control group. MSG markedly destructed glomeruli of the kidney and increased the immunoexpressing of nuclear erythroid-related factor 2 (Nrf2) and tumor necrosis factor-alpha (TNF-a). Conclusions: Administration of crude honey attenuates and improves the kidney pathological changes induced by MSG.

DOI

10.21608/ejhm.2022.277126

Authors

First Name

Hany Salah

Last Name

Mahmoud

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-

Affiliation

1Center of Scientific Foundation for Experimental Studies and Research, Ismailia, Egypt

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Orcid

-

First Name

Eman Mohamed

Last Name

Kamel

MiddleName

-

Affiliation

Department of 2Anatomy and Embryology, Faculty of Medicine, Suez Canal University, Egypt

Email

whiteheart2013@yahoo.com

City

-

Orcid

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First Name

Heba Nageh

Last Name

Gad EL-Hak

MiddleName

-

Affiliation

Department of 3Zoology, Faculty of Sciences, Suez Canal University, Egypt

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-

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-

Orcid

-

First Name

Tahany Saleh

Last Name

Aldayel

MiddleName

-

Affiliation

Department of 4Health Sciences, Clinical Nutrition, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia

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-

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-

Orcid

-

First Name

Heba M.A.

Last Name

Abdelrazek

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-

Affiliation

Departments of 5Physiology,

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-

City

-

Orcid

-

First Name

Yousra Reda Arafa

Last Name

Mohamed

MiddleName

-

Affiliation

6Forensic Medicine & Toxicology

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-

City

-

Orcid

-

First Name

Shebl

Last Name

Noha

MiddleName

-

Affiliation

7Pathology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt

Email

-

City

-

Orcid

-

First Name

Ghada Mohamed

Last Name

Abd Elghany

MiddleName

-

Affiliation

Department of 3Zoology, Faculty of Sciences, Suez Canal University, Egypt

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-

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-

Orcid

-

Volume

89

Article Issue

2

Related Issue

37472

Issue Date

2022-10-01

Receive Date

2022-12-30

Publish Date

2022-10-01

Page Start

7,719

Page End

7,726

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 89_Issue 2_Pages 7719-7726.pdf

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https://ejhm.journals.ekb.eg/article_277126.html

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https://ejhm.journals.ekb.eg/service?article_code=277126

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242

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Potential Ameliorative Effect of Crude Honeybee on Monosodium Glutamate Induced Nephrotoxicity to Male Rats

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Type

Article

Created At

22 Jan 2023