ABSTRACT Background: Generalized anxiety disorder (GAD) is characterized by excessive, uncontrollable and irrational worry; musculoskeletal health refers to the performance of the locomotor system. Anxiety disorders and musculoskeletal disorders have a significant health impact on daily life. Objective: The aim of the current study is to assess the correlation between anxiety and musculoskeletal health in female adolescents with GAD in Kafr El Sheikh. Patients and methods: A total of 50 participant female adolescents with GAD were recruited from outpatient Psychiatry Clinic in Kafr El Sheikh University hospital, from June 2022 until November 2022. Two questionnaires were filled by every participant to assess the correlation between Hamilton Anxiety Rating Scale (HAM-A) to evaluate anxiety and Musculoskeletal Health Questionnaire (MSC-HQ) to evaluate musculoskeletal health. Results: There was a statistically significant negative correlation between most of aspects of HAM-A Scale and most of aspects of MSC-HQ. Higher scores of HAM-A (indicating higher anxiety severity) were associated with lower score of MSC-HQ aspects (indicating higher musculoskeletal disorders severity). The strongest negative correlation was between depressed mood domain of HAM-A Scale and emotional wellbeing domain of MSC-HQ (r= -0.526, p= 0.001), while the weakest negative correlation was between anxious mood domain of HAM-A Scale and fatigue or low energy domain in MSC-HQ (r= -0.282, p= 0.050). Conclusion: In female adolescents with GAD higher anxiety severity is associated with higher musculoskeletal disorders severity and vice versa with strongest correlation between depressed mood and emotional wellbeing.