Background: The ligasure (LS) system is a bipolar diathermy device used to close blood arteries with minimal heat damage to surround tissue. For both benign and malignant thyroid problems, total thyroidectomy is now the standard surgical treatment. Objective: The aim of the current study is to evaluate the effectiveness of the Ligasure small jaw approach versus the standard Clamp and tie method in thyroidectomy. Patients and methods: Our study is a randomized controlled clinical trial was conducted in the General Surgery Department at Zagazig University Hospital on a sample of 30 cases. The patients were divided into 2 groups; Group A includes 15 patients underwent thyroidectomy using Ligasure small jaw technique, and Group B includes 15 patients underwent thyro4idectomy by using traditional Clamp and tie technique. Results: Drainage volume (ml)) among the study groups that ranged from 60 to 110 with mean 81.06 (SD 20.12) in Ligasure group and ranged from 80 to 140 with mean 100.33 (SD 23.48) in Clamp and tie technique group. Group A had significantly smaller drainage volume than Group B (P value 0.024). Postoperative complications occurred more with traditional Clamp and tie technique than Ligasure technique, with no statistically significant difference. Conclusion: When compared to the more common Clamp and tie method, the Ligasure technique reduces surgical time, blood loss during the procedure, the need for postoperative drainage or hematoma, the risk of parathyroid damage, and the risk of recurrent laryngeal nerve injury.