Background: Polycystic Ovarian Syndrome (PCOS) is one of the most prevalent metabolic and reproductive disorders that have been linked to hyperandrogenism, and anovulatory infertility in females of reproductive age. Objective: The aim of the work was to compare the influence of electroacupuncture and ultrasonic cavitation on sex hormones in obese, infertile PCO patients. Patients and Methods: This prospective, single-blind, randomized controlled study included a total of forty obese, infertile PCO women, selected from the Department of Obstetrics and Gynecology, Aga Central Hospital, Egypt. The participants were divided randomly into two groups; Group (A) included twenty infertile, obese PCO women who had been treated with ultrasound cavitation on the abdomen twice a week for three months. Group (B) consisted of twenty infertile, obese PCO women who received electroacupuncture twice a week for 3 months. BMI, WHR, LH, FSH, testosterone, and serum progesterone levels were evaluated at baseline and after the study for both groups. Results: Statistical analysis revealed a highly significant decrease in BMI, WHR, LH, the LH/FSH ratio, and testosterone, in addition to a significant raise in FSH and serum progesterone in the two groups, A and B, after treatment when compared to pre-treatment (P≤0.001). Between the two groups (A and B) pre- and post-treatment, there were no statistically significant differences in the measured variables (p>0.05). Conclusion: It could be concluded that both ultrasound cavitation and electro acupuncture are efficient therapies for treating obese infertile patients with PCOS.