Introduction: Local anesthesia is a technique used to induce the absence of sensation in a specific vital part of the body. The methods for developing durable controlling term acting of local anesthetics mainly include the continuous pumping of drugs around the nerves. The use of a drug delivery system with controlled-release functions, promises the development of new compounds.  Objective: Several notions in literature denoted the use of lidocaine delayed wound healing, and the therapeutic manoeuvres of open wound gated for more than several days, at this time the patient complains of pain, for this reason, the pain reliever and itching during healing phases one of the properly developed uses developed Nano form carrying lidocaine SNL lidocaine as an alternative to conventional lidocaine maintain superior efficacy during the management of open skin wounds through maintaining local anesthesia as an assistant line for managing to wound healing. Patients and Methods: Fifty rabbits were divided into four groups. The full excisional wounds were treated with different formulas, conventional lidocaine, SNL lidocaine, and SNL lidocaine carpabol gel, as a daily dressed treatment. Results: The results of wound healing revealed that Nano lipid loaded lidocaine gel decreased wounds and was faster healed than conventional lidocaine form; higher closure rate and closure velocity and low closure t½. conventional lidocaine delays healing more than other treated groups and control. Conclusion: SNL lidocaine gel turn on accelerated wound healing and overcomes the adverse effect of delaying healing by conventional lidocaine.