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276599

Efficacy of Marik Protocol in the Treatment of Septic Shock (Hydrocortisone, Ascorbic Acid and Thiamine)

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Last updated: 03 Jan 2025

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Abstract

Background: Septic shock is a life-threatening state characterized by inability of the organism to maintain sufficient blood pressure and thus end-organ perfusion because of sepsis. The cornerstones of treatment of sepsis and septic shock largely consist of early diagnosis of sepsis, control of infection source, early antimicrobials and supportive treatment with adequate hydration and vasopressor drugs. Objective: The current study aimed to evaluate the efficacy of Marik protocol treatment for septic shock. Patients and Methods: This was a prospective study that included 100 patients with septic shock who arrived to Emergency Departments of both Al-Azhar and Al-Mansoura University Hospitals over one year (January 2021-December 2021). Entire subjected were divided into a control group who administered a standard treatment and a treatment group who administered IV vitamin C, thiamine and hydrocortisone within 24 h after intensive care unit (ICU) admission. Results: Marik group was linked to a significant decrease in hospital mortality 4 (8%) and ICU mortality rate 45 (90%) in comparison with controls (P<0.001). A significant decrease in SOFA score was recorded among Marik group in comparison with control subjects (P<0.05). A statistically reduction in lactate co concentration during follow-up was recorded in Marik group only. Conclusion: Marik group was linked to a significant reduction in hospital and ICU mortality rate. A significant reduction in SOFA score was recorded among Marik group.  

DOI

10.21608/ejhm.2022.276599

Authors

First Name

Mohamed El-Morsy Abo-Zaid

Last Name

Dora

MiddleName

-

Affiliation

Departments of 1Critical Care

Email

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Orcid

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First Name

Mohamed Elsaid

Last Name

Ahmed

MiddleName

-

Affiliation

Departments of 1Critical Care

Email

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City

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Orcid

-

First Name

Samir Mohamed

Last Name

Attia

MiddleName

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Affiliation

2Vascular Surgery

Email

-

City

-

Orcid

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First Name

Tarek Elsayed

Last Name

Gouda

MiddleName

-

Affiliation

3Internal Medicine, Faculty of Medicine, Mansoura University, Egypt

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Orcid

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Volume

89

Article Issue

2

Related Issue

37472

Issue Date

2022-10-01

Receive Date

2022-12-28

Publish Date

2022-10-01

Page Start

7,497

Page End

7,503

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_276599.html

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https://ejhm.journals.ekb.eg/service?article_code=276599

Order

207

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Efficacy of Marik Protocol in the Treatment of Septic Shock (Hydrocortisone, Ascorbic Acid and Thiamine)

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Article

Created At

22 Jan 2023