Background: Both the platelet/lymphocyte ratio (PLR) and the neutrophil/ lymphocyte ratio (NLR) have the ability to serve as inflammatory biomarkers that indicate the presence of various inflammatory disorders. Aim of the work: This study aimed to ascertain if NLR and PLR are novel biomarkers for axial spondyloarthritis (axSpA) and their connection to illness activity, and to assess how illness activity in axSpA patients relates to NLR and PLR. Subjects and Methods: This research was carried out on 72 Axial SpA patients who were enrolled from Inpatient and Outpatient Clinics in the Rheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig university Hospitals' over a six-month period from February to August 2022. Results: NLR and PLR were statistically substantially greater in active instances compared to non-active instances. Also, in the examined instances, there was a statistically substantial positive connection between NLR and PLR, BASDAI, BASFI, and CRP. ROC analysis and validity of NLR, PLR showed that NLR had significant validity for differentiation between active and non-active cases. PLR had significant validity for differentiation between active and non-active cases at cut off 113.6 with sensitivity 61.1%, specificity 72.2% and accuracy 66.7%.   Conclusion: Our results revealed that NLR and PLR values were linked with disease severity levels, with the median of NLR and PLR being greater in axSpA patients in the active group. Thus, in axSpA patients, they are reliable indicators of inflammation and disease severity.