Background: Coronaviruses are known to cause various diseases. One of them is SARS-CoV-2 which was first reported in 2019. The main risk factor for severe disease is the disorder of coagulation, which can usually happen during the course of the illness. Patients and Method: Adult COVID-19 patients admitted to Al-Zahra teaching hospital in Wasit province between February and July 2020 were studied in different sections of the hospital in cross-sectional, observational cohort research. In the current study. 79 patients were involved, 36 patients previously used aspirin and 43 patients did not. Results: There was a significant relationship between usage of aspirin and the CT scan changes in the lung (P = .005) in aspirin-taken group, while no significant correlation with the D-dimer level (P = >.05) Conclusions: In hospitalized COVID-19 patients, using aspirin before infection may reduce severe outcomes. So a larger randomized controlled research is needed to establish if there is a link between past aspirin use and decreased lung damage and death in COVID-19 individuals.