Background: Colorectal cancers are amongst the most common cancers to occur. They are 3^rd most prevalent and mortality causing cancers. Colorectal cancers incidence has been rising in developing countries. Objective: This study aimed to analyze deeply survival rates in correlation with different epidemiological and pathological factors as well as investigation of patterns of disease failure and relapse. Subjects and Methods: This was a retrospective study of 141 patients of all stages of colorectal cancers being treated at Cairo University Cancer Center (NEMROCK), through the period from 2014 to 2020. Data were followed up until June 2021. Assessments were made according to individual clinicopathological, and clinico-epidemiological specific correlations. Results: Histopathological evaluation revealed that T3 disease was commonest presenting pathology in 40, while nodal stage N1 was commonest in 17%. The most common disease stage at diagnosis was stage 3 in 43% of patients, while 17% were metastatic at time of diagnosis. Initial pathological staging was the most significant factor to affect DFS with patients from stage 1 had significant longer disease free survival (DFS) 45 months VS stage 2 26 months Vs 3 months for stage 4 p value 0.009. Overall survival was also significantly correlated with pathological stage with difference in median OS 60 months VS 10 months between stage 1 and stage 4, respectively p value 0.002 HR 3.3. Conclusion: Pathological staging was the most significant factor affecting survival, while patients with locally advanced rectal cancers were potentially curable and had extended survival rates after receiving full multimodality treatments. Keywords: