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271918

Potential Role of Peroxisome Proliferator-activated Receptor Gamma Coactivator-1 Alpha (PGC-1α) Gene Polymorphism in Patients with Type 2 Diabetes Mellitus

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Last updated: 24 Dec 2024

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Abstract

Background: Peroxisome Proliferator-activated Receptor Gamma Coactivator-1 Alpha (PGC-1α) is a cellular modulator of oxidative and lipid metabolism. It has a vital role in the regulation of mitochondrial activity. Patients with type 2 diabetes mellitus (T2DM) have mitochondrial abnormality and reduced mitochondrial numbers within the cells of skeletal muscles. Objective: To evaluate the correlation between PGC-1α gene polymorphism and T2DM in Egyptian patients attending Zagazig University Hospitals. Patients and Methods: This was a case-control study including 136 participants of both sexes recruited from the Zagazig University Hospitals. The participants were divided into two equal groups: control group with normal individuals and T2DM group with 68 participants in each group. Results: The incidence of A allele was significantly higher in T2DM group. Also, there were statistically significant elevations in waist hip ratio (WHR) and fasting blood sugar (FBS) among carriers of GA and AA genotypes. However, there was no significant correlation between gene polymorphism and lipid profile in T2DM group. After applying multivariate analysis, A allele carriers and increased values of WHR, FBS, HOMA-IR and low-density lipoprotein-cholesterol (LDL-c) were detected in T2DM. Conclusion: We concluded that A allele of PGC-1α polymorphism was a possible predictor of T2DM occurrence in Egyptian patients. Additionally, WHR and FBS were significantly higher among carriers of GA and AA genotypes  

DOI

10.21608/ejhm.2022.271918

Keywords

PGC-1α, Polymorphism, Type 2 diabetes mellitus

Authors

First Name

Abdallah S.

Last Name

Abdelazem

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Orcid

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First Name

Atef Gouda

Last Name

Hussein

MiddleName

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Affiliation

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Email

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City

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Orcid

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First Name

Mayada M.

Last Name

Mousa

MiddleName

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Affiliation

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Email

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City

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Orcid

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First Name

Shaden A. F. Mohammed

Last Name

Assaf

MiddleName

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Affiliation

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Email

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City

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Orcid

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First Name

Samia

Last Name

Hussein

MiddleName

-

Affiliation

Zagazig University

Email

samiahussein82@hotmail.com

City

-

Orcid

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Volume

89

Article Issue

2

Related Issue

37472

Issue Date

2022-10-01

Receive Date

2022-11-30

Publish Date

2022-10-01

Page Start

6,956

Page End

6,960

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_271918.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=271918

Order

130

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Potential Role of Peroxisome Proliferator-activated Receptor Gamma Coactivator-1 Alpha (PGC-1α) Gene Polymorphism in Patients with Type 2 Diabetes Mellitus

Details

Type

Article

Created At

22 Jan 2023