Background: Oral and maxillofacial lesions include a wide variety of lesions. They could be either neoplastic or non-neoplastic, furthermore; the non-neoplastic lesions can be cystic, inflammatory, or they can also represent a reaction to some kind of irritation or mild injury. Objective: To analyze the frequency and distribution of the various types of oral and maxillofacial lesions in Nineveh province. Patients and methods: This retrospective study was conducted on 763 cases from May 2021 to April 2022. Data was retrieved from the Oral Pathology Department at Al-Jumhori Teaching Hospital, Al-Salam Teaching Hospital and some private laboratories in Nineveh province (Iraq). Lesions were classified into four categories: Inflammatory and reactive benign lesions, cystic lesions, benign and malignant lesions. Statistical analysis was done using chi-square test and F test, with p-value <0.05 a significant level. Results: The most commonly affected age was between 11 and 20 years. There were four diagnostic groups; (46.79%) inflammatory and reactive benign lesions, (16.77%) cystic lesions, (22.81%) benign tumors and tumor–like lesions, and (13.63%) malignant tumors. The most frequently encountered inflammatory and reactive benign lesion was non-specific inflammation (11.27%). The most frequently encountered cystic lesion was epidermoid cyst (7.34%). On the other hand, the most frequently encountered benign tumor and tumor-like lesion was nevi (4.33%). Conclusions: Non-specific inflammation is the most common oral and maxillofacial lesions, followed by fibroepithelial polyp.