Background: It has been suggested that an association exists between elevated Fetuin A concentration, obesity, as well as fatty liver. Objective: Investigation of connection between NAFLD and Fetuin A in individuals with or without chronic hepatitis C virus infection in of Egyptian population. Patients and Methods: In a cross-sectional study, we conducted our trial at Misr University for Science and Technology and the Gastroenterology and Hepatology Unit of Ain Shams University's Department of Internal Medicine. The study included 90 patients and were subdivided into three groups, group I included 30 healthy people as control group, group II included 30 patients with NAFLD (non-diabetic) and group III included 30 patients with hepatic steatosis on top of HCV infection non cirrhotic and non-diabetic. Results: Fetuin A level and blood triglyceride were positively correlated in all patients and patient subgroups, both statistically significantly correlated (NAFLD, HCV). There was also highly statistically significant positive correlation between serum cholestrerol and fetuin A level in all patients and in patient subgroups (NAFLD, HCV) and with a cutoff point of >500, the serum level of fetuin A revealed a highly statistically significant difference between groups 1 and 2; serum fetuin A showed a highly statistically significant difference between groups 1 and 3, with a cutoff point of >1800. Conclusion: ROC curve showed the diagnostic performance of serum Fetuin A as a marker in fatty liver.