Background: Bisphenol A (BPA) is one of the most utilized industrial chemicals worldwide. It is commonly found in a variety of consumer products. Taurine is  a natural product; has been shown to protect cells against the cytotoxic effects and inflammations associated with oxidative stress and provide anti-inflammatory effects. Objectives: This study was designed to investigate the toxic effects of BPA on the liver and evaluate the possible protective effect of taurine. Methods: Forty adult male albino rats were divided equally into four groups (10 rats per group). Group I: Rats fed on basal diet and distilled water. Group II: Received taurine orally (100 mg /kg /day). Group III: Rats treated orally with bisphenol (130 mg /kg /day). Group IV received BPA and taurine. After one month, all animals were sacrificed and blood was collected for analysis. Results: There is increased serum AST& ALT level and histopathological changes in liver. Toxic effects declined markedly with taurine co-administration. Conclusions: The present study concluded that BPA has many toxic effects on liver, taurine has a potential protective effect against such harmful effects.