Background: Aluminum phosphide (AlP) is used excessively in Egypt as a fumigant and preservative for the grains. Recently, the suicidal accidents due to AlP poisoning are uprising as it is highly toxic and easily available for vulnerable groups as uneducated individual and teenagers. Objective: This study aims to evaluate the ability of oxidative stress parameters including malondialdehyde (MDA), catalase activity and superoxide dismutase (SOD) to predict the outcome of AlP acute intoxication. Patients and methods: This was a prospective cohort study on 50 cases of AlP-intoxicated cases who presented to Zagazig Poison Control Center, Emergency Department and Intensive Care Units of Zagazig University Hospitals from January 2021 to June 2021, forty-two of them were eligible to be included for age group (20-45). Serum samples were collected within 24 hours post ingestion. Results: serum level of malondialdehyde (MDA) was significantly elevated and catalase activity was markedly declined in the non-survivors compared to the survivors, while SOD had no statistical value. Conclusions: MDA and catalase activity showed good prognostic potential using statistical tests of comparison, although by receiver operating curves, they showed low specificity (41.2% and 76.5% respectively) with possibility of high false positive, while SOD was of no value.